(1’R,2R,3R)-Defluoro Fosaprepitant Dimeglumine
Ref. TR-F727375
| 25mg | 25,376.00 € |
Estimated delivery in United States, on Friday 30 Aug 2024
Product Information
Name:
(1’R,2R,3R)-Defluoro Fosaprepitant Dimeglumine
Controlled Product
Synonyms:
- (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentaol hemi((3-(((2R,3R)-2-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-phenylmorpholino)methyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)phosphonate)
Description:
Applications (1’R,2R,3R)-Defluro Fosaprepitant Dimeglumine is an impurity of Fosaprepitant (F727300) isomer, which is a selective neurokinin-1 (NK-1) receptor antahonist. Fosaprepitant is an antiemetic drug and Aprepitant (A729800) prodrug.
References Tattersall, F., et al.: Neuropharmacol., 39, 652 (2000); Cocquyt, V., et al.: Eur. J. Canc., 37, 835 (2001); Lasseter, K., et al.: J. Clin. Pharmacol., 47, 834 (2007); Marbury, T., et al.: Anesthes., Analges., 109, 418 (2009)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
986.85
Formula:
C37H57F6N6O16P
Color/Form:
Neat
InChI:
InChI=1S/C23H23F6N4O6P.2C7H17NO5/c1-13(15-9-16(22(24,25)26)11-17(10-15)23(27,28)29)39-20-19(14-5-3-2-4-6-14)32(7-8-38-20)12-18-30-21(34)33(31-18)40(35,36)37;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h2-6,9-11,13,19-20H,7-8,12H2,1H3,(H,30,31,34)(H2,35,36,37);2*4-13H,2-3H2,1H3/t13?,19-,20-;2*4-,5+,6+,7+/m100/s1
InChI key:
InChIKey=BLKGRNBEVDABEV-KHKLRGDGSA-N
SMILES:
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.C[C@@H](O[C@@H]1OCCN(Cc2nn(P(=O)(O)O)c(=O)[nH]2)[C@H]1c1ccccc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1
MDL:
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Density:
Concentration:
EINECS:
Merck:
HS code:
Technical inquiry about: TR-F727375 (1’R,2R,3R)-Defluoro Fosaprepitant Dimeglumine
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