Estimated delivery in United States, on Wednesday 26 Jun 2024
Product Information
Name:
Glasdegib
Synonyms:
- Urea
- N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)-
- N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N'-(4-cyanophenyl)urea
- PF 04449913
- N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)urea
- Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)-
CAS:
Description:
Applications Glasdegib acts as a potent, orally biovailablesmoothened (Smo) inhibitor used in the treatment of cancer.
References Shaik, M.et al.: Canc. Chemother. Pharmacol., 74, 411 (2014); Peng, Z. et al.: Org. Lett., 16, 860 (2014);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
374.44
Formula:
C21H22N6O
Color/Form:
Off-White Solid
InChI:
InChI=1S/C21H22N6O/c1-27-11-10-16(24-21(28)23-15-8-6-14(13-22)7-9-15)12-19(27)20-25-17-4-2-3-5-18(17)26-20/h2-9,16,19H,10-12H2,1H3,(H,25,26)(H2,23,24,28)/t16-,19-/m1/s1
InChI key:
InChIKey=HBEHXEHXMWPSKO-XLKSUYJWSA-N
SMILES:
C[C@]12CC[C@H]3c4ccc(O)cc4C[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)[C@H]3[C@H]1CC[C@@H]2O[C@@H]1OC(C(=O)O)[C@H](O)C(O)C1O
MDL:
Melting point:
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Flash point:
Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-G406550 Glasdegib
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