Estimated delivery in United States, on Tuesday 21 May 2024
Product Information
Name:
GSK360A
Controlled Product
Synonyms:
- N-[[1-(2-Cyclopropylethyl)-6-fluoro-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl]carbonyl]glycine
- N-[[1-(2-Cyclopropylethyl)-6-fluoro-4-hydroxy-2-oxo-1,2-dihydro-3-quinolinyl]carbonyl]glycine
CAS:
Description:
Applications GSK360A orally active HIF-PHD inhibitor. GSK360A exerts systemic and local effects by stabilizing HIF-1α signaling and improves long-term ventricular function, remodeling, and vascularity in a model of established ventricular dysfunction. These findings suggest that GSK360A may be suitable for the treatment of post-MI remodeling and heart failure.
References Bao, W.-K. et al.: J. Cardio. Pharmacol., 56, 147 (2010);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
348.33
Formula:
C17H17FN2O5
Color/Form:
Pale Beige to Beige Solid
InChI:
InChI=1S/C17H17FN2O5/c18-10-3-4-12-11(7-10)15(23)14(16(24)19-8-13(21)22)17(25)20(12)6-5-9-1-2-9/h3-4,7,9,23H,1-2,5-6,8H2,(H,19,24)(H,21,22)
InChI key:
InChIKey=TYHRZQVUPPODPT-UHFFFAOYSA-N
SMILES:
O=C(O)CNC(=O)c1c(O)c2cc(F)ccc2n(CCC2CC2)c1=O
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
Technical inquiry about: TR-G797600 GSK360A
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