6-Hydroxy-(S,S)-Palonosetron

CAS: 2446343-19-5

Ref. TR-H114855

Product Information

• Name: 6-Hydroxy-(S,S)-Palonosetron
• Synonyms: (3aS)-6-hydroxy-2-((S)-quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one

Description

Applications 6-Hydroxy-(S,S)-Palonosetron is an intermediate used in the synthesis of 6-Oxo-(S,S)-Palonosetron (O858568), which is an impurity of (S,S)-Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 312.41
• Formula: C₁₉H₂₄N₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C19H24N2O2/c22-17-5-4-13-10-21(16-11-20-8-6-12(16)7-9-20)19(23)15-3-1-2-14(17)18(13)15/h1-3,12-13,16-17,22H,4-11H2/t13-,16-,17?/m1/s1
• InChI key: InChIKey=TZDXMUXWGXFPLG-ZIAVVELASA-N
• SMILES: O=C1c2cccc3c2[C@H](CCC3O)CN1[C@@H]1CN2CCC1CC2