p-Hydroxycocaine Hydrochloride

CAS: 197771-77-0

Ref. TR-H825445

Product Information

• Name: p-Hydroxycocaine Hydrochloride
• Synonyms: (1R,2R,3S,5S)-3-[(4-Hydroxybenzoyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester Hydrochloride, [1R-(exo,exo)]-3-[(4-Hydroxybenzoyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester Hydrochloride, 4'-Hydroxybenzoylecgonine Methyl Ester Hydrochloride, 4'-Hydroxycocaine Hydrochloride

Description

Applications: p-Hydroxycocaine is a metabolite of Cocaine (HCl: C633500), a vasoconstrictive agent that is highly addictive and has high potential for abuse. The mechanism by which Cocaine induces dependence is unknown, but it is hypothesized that it works by blocking the dopamine transporter, increasing the amount of free dopamine in the brain.
References Carrera, M., et al.: Nature, 378, 727 (1995); Moore, T., et al.: Am. J. Obst. Gyne., 155, 883 (1986); Volkow, N., et al.: Nature, 386, 827 (1997)

• Brand: TRC

Chemical properties

• Molecular weight: 355.81
• Formula: C₁₇H₂₁NO₅·HCl
• Color/Form: Neat
• InChI: InChI=1S/C17H21NO5.ClH/c1-18-11-5-8-13(18)15(17(21)22-2)14(9-11)23-16(20)10-3-6-12(19)7-4-10;/h3-4,6-7,11,13-15,19H,5,8-9H2,1-2H3;1H/t11-,13+,14-,15+;/m0./s1
• InChI key: InChIKey=AOSQZYJCIGWNGT-HLYGUNNVSA-N
• SMILES: COC(=O)[C@H]1[C@@H](OC(=O)c2ccc(O)cc2)C[C@@H]2CC[C@H]1N2C.Cl