2-Hydroxy Atorvastatin-d5 Sodium Salt

CAS: 1276537-19-9

Ref. TR-H828952

Product Information

• Name: 2-Hydroxy Atorvastatin-d5 Sodium Salt
• Synonyms: 1H-Pyrrole-1-heptanoic acid, 2-(4-fluorophenyl)-ß,d-dihydroxy-4-[[(2-hydroxyphenyl)amino]carbonyl]-5-(1-methylethyl)-3-(phenyl-2,3,4,5,6-d5)-, sodium salt (1:2), (ßR,dR)-, 2-Hydroxy Atorvastatin-d5 Disodium Salt
• CAS: 1276537-19-9

Description

Applications A deuterated metabolite of Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Smith, S., et al.: Am. J. Cardiol., 80, 10H (1997), Jacobsen, W., et al.: Drug Metab. Dispos., 28, 1369 (2000), Istvan, E., et al.: Science, 292, 1160 (2001), Tabernero, L., et al.: J. Biol. Chem., 278, 19933 (2003), Bratton, L., et al.: Bioorg. Med. Chem., 15, 5576 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 623.63
• Formula: C₃₃H₃₀D₅FN₂O₆•xNa
• Color/Form: Neat
• InChI: InChI=1S/C33H35FN2O6.2Na/c1-20(2)31-30(33(42)35-26-10-6-7-11-27(26)39)29(21-8-4-3-5-9-21)32(22-12-14-23(34)15-13-22)36(31)17-16-24(37)18-25(38)19-28(40)41;;/h3-15,20,24-25,37-39H,16-19H2,1-2H3,(H,35,42)(H,40,41);;/q;2*+1/p-2/t24-,25-;;/m1../s1/i3D,4D,5D,8D,9D
• InChI key: InChIKey=CZBPKFICAYVHHM-GHGSXRDVSA-N
• SMILES: [2H]c1c([2H])c([2H])c(-c2c(C(=O)Nc3ccccc3O)c(C(C)C)n(CC[C@H](O)C[C@@H](O)CC(=O)O)c2-c2ccc(F)cc2)c([2H])c1[2H]