-Hydroxycocaine Hydrochloride

CAS: 197771-76-9

Ref. TR-H922195

Product Information

• Name: -Hydroxycocaine Hydrochloride
• Synonyms: 2'-Hydroxybenzoylecgonine Methyl Ester hydrochloride, (1R,2R,3S,5S)-Methyl 3-((2-Hydroxybenzoyl)oxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride, [1R-(exo,exo)]-3-[(2-hydroxybenzoyl)oxy]-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic Acid Methyl Ester hydrochloride
• CAS: 197771-76-9

Description

Applications 2'-Hydroxycocaine is a metabolite of Cocaine (C633500), which Inhibits the dopamine, norepinephrine, and serotonin transporters and is a local anesthetic. Measurement of hydroxycocaine metabolites in hair can be used as evidence of cocaine ingestion.
References Blakely, R.D., et al.: Curr. Opin. Neurobiol., 10, 328 (2000); Cowell, R. M., et al.: Eur. J. Pharmacol., 389, 59 (2000); Fleckenstein, A.E., Eur. J. Pharmacol., 406, 1 (2000); Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003); Schaffer, M., et al.: Anal. Bioanal. Chem., 408, 2043 (2016);

• Brand: TRC

Chemical properties

• Molecular weight: 355.81
• Formula: C₁₇H₂₁NO₅·HCl
• InChI: InChI=1S/C17H21NO5.ClH/c1-18-10-7-8-12(18)15(17(21)22-2)14(9-10)23-16(20)11-5-3-4-6-13(11)19, /h3-6,10,12,14-15,19H,7-9H2,1-2H3, /m0./s1, 1H/t10-,12+,14-,15+
• InChI key: InChIKey=PEISRHQJLATJPJ-MMMKDXCPSA-N
• SMILES: COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2O)C[C@@H]2CC[C@H]1N2C