14-Hydroxy Norcodeinone

CAS: 2302-68-3

Ref. TR-H922210

Product Information

• Name: 14-Hydroxy Norcodeinone
• Synonyms: (5a)-7,8-didehydro-4,5-epoxy-14-hydroxy-3-methoxy-Morphinan-6-one, 14-hydroxynorcodeinone, N-Noroxycodeinone, Norhydroxycodeinone

Description

Applications 14-Hydroxy Norcodeinone is an inertermediate in the synthesis of N-Allyldihydro-8,10,14-trihydroxynormorphinone (A549610), an impurity of Naloxone (HCl salt, N285000) which is a specific opioid antagonist and narcotic antagonist.
References Jasinski, D.R., et al.: J. Pharmacol. Exp. Ther., 157, 420 (1967); McNicholas, L.F., et al.: Drugs, 27, 81 (1984); Hasson, M.M.A., et al.: Anal. Profiles Drug Subs., 14, 453 (1985); Stowe, C., et al.: Ann. Pharmacother., 27, 447 (1993)

• Brand: TRC

Chemical properties

• Molecular weight: 299.32
• Formula: C₁₇H₁₇NO₄
• Color/Form: Neat
• InChI: InChI=1S/C17H17NO4/c1-21-11-3-2-9-8-12-17(20)5-4-10(19)15-16(17,6-7-18-12)13(9)14(11)22-15/h2-5,12,15,18,20H,6-8H2,1H3/t12-,15+,16+,17-/m1/s1
• InChI key: InChIKey=WCEICHOCRFRVDG-ISWURRPUSA-N
• SMILES: COc1ccc2c3c1O[C@H]1C(=O)C=C[C@@]4(O)[C@@H](C2)NCC[C@]314