2-Hydroxydesipramine Dihydrochloride

CAS: 59259-75-5

Ref. TR-H936505

Product Information

• Name: 2-Hydroxydesipramine Dihydrochloride
• Synonyms: 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepin-2-ol Dihydrochloride

Description

Applications 2-Hydroxydesipramine Dihydrochloride is a metabolite of Desipramine (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981); Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984); Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987); Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981); Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998); Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999); Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003)

• Brand: TRC

Chemical properties

• Molecular weight: 355.3
• Formula: C₁₈H₂₂N₂O·2HCl
• Color/Form: Neat
• InChI: InChI=1S/C18H22N2O.2ClH/c1-19-11-4-12-20-17-6-3-2-5-14(17)7-8-15-13-16(21)9-10-18(15)20;;/h2-3,5-6,9-10,13,19,21H,4,7-8,11-12H2,1H3;2*1H