(E)-4-Hydroxy-N-desmethyl Tamoxifen

CAS: 114828-90-9

Ref. TR-H938495

Product Information

• Name: (E)-4-Hydroxy-N-desmethyl Tamoxifen
• Synonyms: 4-[(1E)-1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]phenol, E-Endoxifen
• CAS: 114828-90-9

Description

Applications A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
References Furr, B., et al.: Pharmacol. Ther., 25, 127 (1984), Leonessa, F., et al.: Cancer Res., 54, 441 (1994), Stearns, V., et al.: Lancet, 360, 1851 (2002), Rae, J., et al.: Pharmacogenetics, 13, 501 (2003),

• Brand: TRC

Chemical properties

• Molecular weight: 373.49
• Formula: C₂₅H₂₇NO₂
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3/b25-24+
• InChI key: InChIKey=MHJBZVSGOZTKRH-OCOZRVBESA-N
• SMILES: CC/C(=C(/c1ccc(O)cc1)c1ccc(OCCNC)cc1)c1ccccc1