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2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid
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2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid

CAS: 1245157-42-9

Ref. TR-H939020

10mg
375.00 €
50mg
1,591.00 €
100mg
2,843.00 €
Estimated delivery in United States, on Tuesday 18 Feb 2025

Product Information

Name:
2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid
Controlled Product
Description:

Applications 2-[[6-[4-(2-Hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxylic acid is an intermediate in the preparation of Dasatinib (D193600), a new, oral, small-molecule Tyrosine Kinase Inhibitor (TKI) for the treatment of CML. Antineoplastic.
References Lombardo, L.J., et al: J. Med. Chem., 47, 6658 (2004); Shah, N. P., et al.: Science, 305, 399 (2004); O’Hare, T., et al.: Curr. Opin. Genet. Dev., 16, 92 (2006); Yan, R., et al.: Faming Zhuanli Shenqing (2010), CN 101845045 A 20100929

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
364.42
Formula:
C15H20N6O3S
Color/Form:
Neat
InChI:
InChI=1S/C15H20N6O3S/c1-10-17-12(19-15-16-9-11(25-15)14(23)24)8-13(18-10)21-4-2-20(3-5-21)6-7-22/h8-9,22H,2-7H2,1H3,(H,23,24)(H,16,17,18,19)
InChI key:
InChIKey=MGXNUQLLDXXAOP-UHFFFAOYSA-N
SMILES:
Cc1nc(Nc2ncc(C(=O)O)s2)cc(N2CCN(CCO)CC2)n1
MDL:
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EINECS:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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