6-Alpha-Hydroxy Paclitaxel (~90%)

CAS: 153212-75-0

Ref. TR-H948890

Product Information

• Name: 6-Alpha-Hydroxy Paclitaxel (~90%)
• Synonyms: 6α-Hydroxy Taxol, (2alpha,3xi,5beta,6alpha,7beta,10beta,13alpha)-4,10-bis(acetyloxy)-1,6,7-trihydroxy-13-({(2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoyl}oxy)-9-oxo-5,20-epoxytax-11-en-2-yl benzoate, 6-Alpha-Hydroxy Paclitaxel, 6-Hydroxylpaclitaxel, 6a-Hydroxy Paclitaxel, 6a-Hydroxy Taxo, 6a-Hydroxy Taxol, 6α-Hydroxypaclitaxel, 6α-Hydroxytaxol, 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv., Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,3S,4R,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-, Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-3,4,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,3α,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

Description

Applications The major human metabolite of Paclitaxel.
References Walle, T., et al.: Biochem. Pharm., 46, 1661 (1993), Kumar, G., et al.: Drug Metab. Dispos., 22, 177 (1994),

• Brand: TRC

Chemical properties

• Molecular weight: 869.91
• Formula: C₄₇H₅₁NO₁₅
• Purity: ~90%
• Color/Form: Neat
• InChI: InChI=1S/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36?,37-,39+,40-,45-,46+,47+/m0/s1
• InChI key: InChIKey=NDCWHEDPSFRTDA-FJMWQILYSA-N
• SMILES: CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)[C@H](O)[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C