17-Hydroxy-3-oxo-17Alpha-pregna-4,20-diene-21-carboxylic Acid Gamma-Lactone

CAS: 52845-59-7

Ref. TR-H949013

Product Information

• Name: 17-Hydroxy-3-oxo-17Alpha-pregna-4,20-diene-21-carboxylic Acid Gamma-Lactone
• Synonyms: (2'R,8R,9S,10R,13S,14S)-10,13-Dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione, SC 4988, Spiro[17H-cyclopenta[a]phenanthrene-17,2'(5'H)-furan] Pregna-4,20-diene-21-carboxylic Acid Derivative, (17alpha)-17-Hydroxy-3-oxo-pregna-4,20-diene-21-carboxylic Acid gamma-Lactone

Description

Applications 17-Hydroxy-3-oxo-17α-pregna-4,20-diene-21-carboxylic Acid γ-Lactone is an intermediate in synthesizing 20,21-Dehydro Spironolactone (D229405), which is an impurity of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.
References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975);

• Brand: TRC

Chemical properties

• Molecular weight: 340.46
• Formula: C₂₂H₂₈O₃
• Color/Form: Gray Solid
• InChI: InChI=1S/C22H28O3/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21)12-8-19(24)25-22/h8,12-13,16-18H,3-7,9-11H2,1-2H3/t16-,17+,18+,20+,21+,22-/m1/s1
• InChI key: InChIKey=BGUOVGQHDRRBST-WNHSNXHDSA-N
• SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@@]21C=CC(=O)O1