N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide

Ref. TR-H950690

Product Information

• Name: N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide

Description

Applications N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.
References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)

• Brand: TRC

Chemical properties

• Molecular weight: 424.29
• Formula: C₁₆H₁₁F₃N₆O₅
• Color/Form: Neat
• InChI: InChI=1S/C16H11F3N6O5/c17-6-1-8(18)7(9(19)2-6)3-20-13(27)11-12(26)14(28)24-10(23-11)4-21-15(29)16-25-22-5-30-16/h1-2,5,26H,3-4H2,(H,20,27)(H,21,29)(H,23,24,28)
• InChI key: InChIKey=BHANRQMQNOCRAJ-UHFFFAOYSA-N
• SMILES: O=C(NCc1nc(C(=O)NCc2c(F)cc(F)cc2F)c(O)c(=O)[nH]1)c1nnco1