5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers)
CAS: 504413-73-4
Ref. TR-H954455
| 1mg | 260.00 € | ||
| 10mg | 1,747.00 € |
Estimated delivery in United States, on Tuesday 14 Jan 2025
Product Information
Name:
5-Hydroxy Topotecan Dihydrochloride (Mixture of Diastereomers)
Controlled Product
Synonyms:
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-[(dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-
- (4S)-
- (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9,12-trihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- 10-Hydroxy-9-[(dimethylamino)methyl]-5-hydroxy-(20S,5RS)-camptothecin
Description:
Stability Hygroscopic
Applications Dihydrochloride Salt of 5-Hydroxy Topotecan, is the metabolite of Topotecan (T542500), which is a DNA topoisomerase I inhibitor, semi synthetic analog of Camptothecin, and an antineoplastic.
References Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990), BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1991), Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1992),
Notice:
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Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
437.45
Formula:
C23H23N3O6
Color/Form:
Neat
InChI:
InChI=1S/C23H23N3O6/c1-4-23(31)15-8-17-19-12(20(28)26(17)21(29)14(15)10-32-22(23)30)7-11-13(9-25(2)3)18(27)6-5-16(11)24-19/h5-8,20,27-28,31H,4,9-10H2,1-3H3/t20?,23-/m0/s1
InChI key:
InChIKey=IKBVYIZOTSVDNQ-AKRCKQFNSA-N
SMILES:
CC[C@@]1(O)C(=O)OCc2c1cc1n(c2=O)C(O)c2cc3c(CN(C)C)c(O)ccc3nc2-1
MDL:
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EINECS:
Merck:
HS code:
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