Product Information
Name:
Hypothemycin
Synonyms:
- [1aR-(1aR*,3S*,4S*,6Z,9S*,15bR*)]-1a,8,9,15b-Tetrahydro-3,4,12-trihydroxy-14-methoxy-9-methyl-3H-oxireno[k][2]benzoxacyclotetradecin-5,11(2H,4H)-dione
- NSC 354462
- f 152 D2
Description:
Applications Hypothemycin is a potent and selective inhibitor of threonine/tyrosine-specific kinase, MEK, and other protein kinases that contain a conserved cysteine residue in the ATP-binding site in in vitro studies.
References Zhao, A., et al.: J. Antibiotics, 52, 1086 (1999); Schirmer, A., et al.: Proc. Nat. Acad. Sci. U. S. A., 103, 4234 (2006); Winssinger, M., et al.: Chem. Comm., 1, 22 (2007)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
378.37
Formula:
C19H22O8
Color/Form:
White to Off-White Solid
InChI:
InChI=1S/C19H22O8/c1-9-4-3-5-12(20)17(23)14(22)8-15-18(27-15)11-6-10(25-2)7-13(21)16(11)19(24)26-9/h3,5-7,9,14-15,17-18,21-23H,4,8H2,1-2H3/b5-3-/t9-,14-,15+,17+,18+/m0/s1
InChI key:
InChIKey=WXKUAYVKUKAIQR-UHFFFAOYSA-N
SMILES:
Cn1nc(C(=O)OC(=O)c2nn(C)c3ccccc23)c2ccccc21
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