N-[3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)phenyl]-4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]Benzamide

CAS: 2119583-26-3

Ref. TR-I355005

Product Information

• Name: N-[3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)phenyl]-4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]Benzamide
• Synonyms: Desmethylimidazole Nilotinib, Benzamide, N-[3-(1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-, N-[3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)phenyl]-4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzamide, Desmethyl Nilotinib, Desmethylnilotinib
• CAS: 2119583-26-3

Description

Applications N-[3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)phenyl]-4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]Benzamide, is an imurtiy of Nilotinib (N465300), that might be useful in treatment of chronic myelogenous leukemia.
References Corbin, A., et al.: J. Biol. Chem., 277, 32214(2002), Golemovic, M., et al.: Clin. Cancer Res., 11, 4941 (2005), Gleixner, K., et al.: Blood, 107, 752 (2006), Nicolini, F., et al.: Leukemia, 20, 1061 (2006),

• Brand: TRC

Chemical properties

• Molecular weight: 515.49
• Formula: C₂₇H₂₀F₃N₇O
• Color/Form: Pale Yellow to Pale Beige Solid
• InChI: InChI=1S/C27H20F3N7O/c1-17-4-5-18(11-24(17)36-26-33-8-6-23(35-26)19-3-2-7-31-15-19)25(38)34-21-12-20(27(28,29)30)13-22(14-21)37-10-9-32-16-37/h2-16H,1H3,(H,34,38)(H,33,35,36)
• InChI key: InChIKey=WPFXDYJRTVFSEV-UHFFFAOYSA-N
• SMILES: Cc1ccc(C(=O)Nc2cc(-n3ccnc3)cc(C(F)(F)F)c2)cc1Nc1nccc(-c2cccnc2)n1