Isobarbituric Acid

CAS: 496-76-4

Ref. TR-I780030

Product Information

• Name: Isobarbituric Acid
• Synonyms: Fluorouracil Imp. B (EP), Fluorouracil USP Related Compound B, Fluorouracil USP RC B, Dihydropyrimidine-2,4,5(3H)-trione, 5-Hydroxyuracil, Fluorouracil Related Compound B, Fluorouracil Impurity B, 1,3-Diazinane-2,4,5-trione, 2,4,5(3H)-Pyrimidinetrione, dihydro-, 5-hydroxypyrimidine-2,4(1H,3H)-dione, Dihydro-2,4,5(3H)-pyrimidinetrione, Isobarbituric acid, NSC 95958, dihydropyrimidine-2,4,5(3H)-trione
• CAS: 496-76-4

Description

Impurity Fluorouracil EP Impurity B; Fluorouracil USP Related Compound B
Applications A 5-hydroxy derivative of the nucleobase Uracil (U801000) and an isomer of Barbituric Acid (B118650). Studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. Fluorouracil EP Impurity B. Fluorouracil USP Related Compound B
References Varatharasa T. et al.: Chem. Comm., 3, 400 (2005); Jaruga, P. et al.: Nucleic Acid Res., 24, 1389 (1996); Rodriguez, H. et al.: Adv. Exp. Med. Biol., 534, 129 (2003);

• Brand: TRC

Chemical properties

• Molecular weight: 128.09
• Formula: C₄H₄N₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C13H19Cl/c1-9-6-11(13(3,4)5)7-10(2)12(9)8-14/h6-7H,8H2,1-5H4
• InChI key: InChIKey=FQXOOGHQVPKHPG-UHFFFAOYSA-N
• SMILES: O=C1NCC(=O)C(=O)N1