JNJ-7706621

CAS: 443797-96-4

Ref. TR-J211310

Product Information

• Name: JNJ-7706621
• Synonyms: N3-[4-(Aminosulfonyl)phenyl]-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazole-3,5-diamine, 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-yl]amino]benzenesulfonamide, JNJ 770662, Jnj-7706621
• CAS: 443797-96-4

Description

Applications JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma.
References Matsuhashi, A. et al.: Curr. Cancer Drug Tar., 12, 625 (2012); Emanue,l S. et al.: Cancer Res., 65, 9038 (2005); Seamon, J.A. et al.: Mol. Cancer Ther., 5, 2459 (2006);

• Brand: TRC

Chemical properties

• Molecular weight: 394.356
• Formula: C₁₅H₁₂F₂N₆O₃S
• Color/Form: Neat
• InChI: InChI=1S/C15H12F2N6O3S/c16-10-2-1-3-11(17)12(10)13(24)23-14(18)21-15(22-23)20-8-4-6-9(7-5-8)27(19,25)26/h1-7H,(H2,19,25,26)(H3,18,20,21,22)
• InChI key: InChIKey=KDKUVYLMPJIGKA-UHFFFAOYSA-N
• SMILES: N=c1nc(Nc2ccc(S(N)(=O)=O)cc2)[nH]n1C(=O)c1c(F)cccc1F