(+)-cis-Khellactone

CAS: 24144-61-4

Ref. TR-K432105

Product Information

• Name: (+)-cis-Khellactone
• Synonyms: (9R,10R)-9,10-Dihydro-9,10-dihydroxy-8,8-dimethyl-2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, (9R-cis)-9,10-Dihydro-9,10-dihydroxy-8,8-dimethyl-2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one, 9,10-Dihydro-9,10-dihydroxy-8,8-dimethyl-2H,8H-Benzo[1,2-b:3,4-b']dipyran-2-one Stereoisomer, (3'R,4'R)-(+)-cis-Khellactone
• CAS: 24144-61-4

Description

Applications (+)-cis-Khellactone is an intermediate in the synthesis of rac Samidin (S110500), a potent vasodilatory agent isolated from Ammi visnaga. cis-Khellactone is a coumarin agent which displays potential P-glycoprotein modulation activity. Antiplatelet aggregation.
References Okuyama, T., et al.: Planta Med., 42, 89 (1981); Matsuda, H., et al.: Chem. Pharm. Bull, 48, 1429 (2000); Abad, M., et al.: Pharm. Pharmacol., 53, 1163 (2001); Jong, T. et al: J. Nat. Prod., 55, 1396 (1992); Shen, X. et al.: J. Pharm. Pharmacol., 64, 90 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 262.26
• Formula: C₁₄H₁₄O₅
• Color/Form: Tan Powder
• InChI: InChI=1S/C14H14O5/c1-14(2)13(17)11(16)10-8(19-14)5-3-7-4-6-9(15)18-12(7)10/h3-6,11,13,16-17H,1-2H3/t11-,13-/m1/s1
• InChI key: InChIKey=HKXQUNNSKMWIKJ-DGCLKSJQSA-N
• SMILES: CC1(C)Oc2ccc3ccc(=O)oc3c2[C@@H](O)[C@H]1O