Product Information
- 1-(2-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-propylurea
- Krn-633
- 1-(2-Chloro-4-(6,7-Dimethoxyquinazolin-4-Yloxy)Phenyl)-3-Propylurea
- Krn633
Applications KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.
References Fediriv, O., et al.: Proc. Natl. Acad. Sci. USA, 104, 20523 (2007); Nakamura, K., et al.: Mol. Cancer. Ther., 3, 1639 (2004)