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KRN 633
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KRN 633

CAS: 286370-15-8

Ref. TR-K659500

1mg
Discontinued
5mg
Discontinued
10mg
Discontinued

Discontinued product. For inquiries about similar products, please fill out our form or email us at .


Product Information

Name:
KRN 633
Synonyms:
  • 1-(2-Chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-propylurea
  • Krn-633
  • 1-(2-Chloro-4-(6,7-Dimethoxyquinazolin-4-Yloxy)Phenyl)-3-Propylurea
  • Krn633
Description:

Applications KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.
References Fediriv, O., et al.: Proc. Natl. Acad. Sci. USA, 104, 20523 (2007); Nakamura, K., et al.: Mol. Cancer. Ther., 3, 1639 (2004)

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
416.86
Formula:
C20H21ClN4O4
Color/Form:
Off-White Solid
InChI:
InChI=1S/C20H21ClN4O4/c1-4-7-22-20(26)25-15-6-5-12(8-14(15)21)29-19-13-9-17(27-2)18(28-3)10-16(13)23-11-24-19/h5-6,8-11H,4,7H2,1-3H3,(H2,22,25,26)
InChI key:
InChIKey=VPBYZLCHOKSGRX-UHFFFAOYSA-N
SMILES:
CCCNC(=O)Nc1ccc(Oc2ncnc3cc(OC)c(OC)cc23)cc1Cl
MDL:
Melting point:
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Density:
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EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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