Estimated delivery in United States, on Thursday 30 May 2024
Product Information
Name:
LEE 011
Controlled Product
Synonyms:
- 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide
- 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-
- 7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
- Kisqali
- LEE 011A
- Ribociclib
- 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-
- Lee 011A
CAS:
Description:
Applications LEE 011 can be used in biological study of kinome-wide RNA interference screen reveals a role for PDK1 in acquired resistance to CDK4/6 inhibition in ER-positive breast cancer.
References Jansen, V. M., et al.: Cancer Research, 77, 2488 (2017)
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
434.54
Formula:
C23H30N8O
Color/Form:
Neat
InChI:
InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
InChI key:
InChIKey=RHXHGRAEPCAFML-UHFFFAOYSA-N
SMILES:
CN(C)C(=O)c1cc2c[nH]c(=Nc3ccc(N4CCNCC4)cn3)nc2n1C1CCCC1
MDL:
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EINECS:
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HS code:
Technical inquiry about: TR-L178830 LEE 011
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