Product Information
Name:
LPYFD-NH2 Trifluoroacetic Acid Salt
Synonyms:
- L-Leucyl-L-prolyl-L-tyrosyl-L-phenylalanyl-L-alpha-asparagine Trifluoroacetic Acid Salt
- Leu-Pro-Tyr-Phe-Asp-NH2 TFA
Description:
Applications LPYFD-NH2 is a neuroprotective peptide that binds to amyloid beta (Aβ). LPYFD-NH2 protects neurons against toxic effects of Aβ (1-42) in vitro and in vivo. LPYFD-NH2 is a potential therapeutic in the treatment of Alzheimer's Disease.
References Wisniewski, T., et al.: Neurobiol. Dis., 4, 313 (1997), Wang, J., et al.: Exp. Neurol., 158, 328 (1999), Dahlgren, K., et al.: J. Biol. Chem. 277, 32046 (2002), Forman, M., et al.: Neurology, 68, 757 (2007),
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
766.761
Formula:
C35H45F3N6O10
Color/Form:
White SOlid
InChI:
InChI=1S/C33H44N6O8.C2HF3O2/c1-19(2)15-23(34)33(47)39-14-6-9-27(39)32(46)38-26(17-21-10-12-22(40)13-11-21)31(45)37-25(16-20-7-4-3-5-8-20)30(44)36-24(29(35)43)18-28(41)42;3-2(4,5)1(6)7/h3-5,7-8,10-13,19,23-27,40H,6,9,14-18,34H2,1-2H3,(H2,35,43)(H,36,44)(H,37,45)(H,38,46)(H,41,42);(H,6,7)/t23-,24-,25-,26-,27+;/m0./s1
InChI key:
InChIKey=IXZJYLXIKGCIAF-AUFFENBXSA-N
SMILES:
CC(C)C[C@H](N)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(N)=O.O=C(O)C(F)(F)F
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