Dimepheptanol

CAS: 545-90-4

Ref. TR-M225893

Product Information

• Name: Dimepheptanol
• Synonyms: Bimethadol, Methadol, NIH 2933, Pangerin, Racemethadol, ß-[2-(Dimethylamino)propyl]-a-ethyl-ß-phenylbenzeneethanol, 6-Dimethylamino-4,4-diphenyl-3-heptanol, 3-Heptanol, 6-(dimethylamino)-4,4-diphenyl-, 6-Dimethylamino-4,4-Diphenylheptan-3-Ol, Benzeneethanol, β-[2-(dimethylamino)propyl]-α-ethyl-β-phenyl-, Nih 2933, β-[2-(Dimethylamino)propyl]-α-ethyl-β-phenylbenzeneethanol

Description

Applications Methadol is an intermediate in synthesizing Acetylmethadol Hydrochloride (A186330), a synthetic opioid similar in structure to Methadone (M225865, HCl) used in the treatment of opiate dependence. It acts as a μ-opioid receptor agonist. It also acts as a potent, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist.
References Billings, R.E. et al.: Life Sci., 14, 1437 (1974); Galici, R. et al.: Pharmacol. Biochem. Behav., 81, 626 (2005); Xiao, Y. et al.: J. Pharmacol. Exp. Therap., 299, 366 (2001)

• Brand: TRC

Chemical properties

• Molecular weight: 311.46
• Formula: C₂₁H₂₉NO
• Color/Form: Neat
• InChI: InChI=1S/C21H29NO/c1-5-20(23)21(16-17(2)22(3)4,18-12-8-6-9-13-18)19-14-10-7-11-15-19/h6-15,17,20,23H,5,16H2,1-4H3
• InChI key: InChIKey=QIRAYNIFEOXSPW-UHFFFAOYSA-N
• SMILES: CCC(O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1