N-(4-methylbenzenesulfonamide) Tolafentrine
Ref. TR-M289790
| 1mg | Discontinued | ||
| 500µg | Discontinued | ||
| 2500µg | Discontinued |
Product Information
Name:
N-(4-methylbenzenesulfonamide) Tolafentrine
Synonyms:
- N-(4-((4aS,10bR)-8,9-Dimethoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)phenyl)-4-methyl-N-tosylbenzenesulfonamide
Description:
Applications N-(4-methylbenzenesulfonamide) Tolafentrine is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
References Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
659.815
Formula:
C35H37N3O6S2
Color/Form:
Light Yellow Solid
InChI:
InChI=1S/C35H37N3O6S2/c1-23-6-14-27(15-7-23)45(39,40)38(46(41,42)28-16-8-24(2)9-17-28)26-12-10-25(11-13-26)35-30-21-34(44-5)33(43-4)20-29(30)31-22-37(3)19-18-32(31)36-35/h6-17,20-21,31-32H,18-19,22H2,1-5H3/t31-,32-/m0/s1
InChI key:
InChIKey=PZERWNOCNZEZJV-ACHIHNKUSA-N
SMILES:
COc1cc2c(cc1OC)[C@@H]1CN(C)CC[C@@H]1N=C2c1ccc(N(S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c2ccc(C)cc2)cc1
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