6-Methylthioguanine

CAS: 1198-47-6

Ref. TR-M330720

Product Information

• Name: 6-Methylthioguanine
• Synonyms: 9H-Purin-2-amine, 6-(methylthio)-, 1H-Purin-2-amine, 6-(methylthio)- (9CI), Purine, 2-amino-6-(methylthio)- (6CI,7CI,8CI), 6-(Methylthio)-9H-purin-2-amine, 2-Amino-6-methylmercaptopurine, 2-Amino-6-methylthiopurine, NSC 29420, S-Methyl-6-thioguanine, S6-Methyl-6-thioguanine

Description

Applications A metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);

• Brand: TRC

Chemical properties

• Molecular weight: 181.22
• Formula: C₆H₇N₅S
• Color/Form: White
• InChI: InChI=1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
• InChI key: InChIKey=YEGKYFQLKYGHAR-UHFFFAOYSA-N
• SMILES: CSc1nc(=N)[nH]c2[nH]cnc12