6a-Methylprednisolone 21-Hemisuccinate

CAS: 2921-57-5

Ref. TR-M331195

Product Information

• Name: 6a-Methylprednisolone 21-Hemisuccinate
• Synonyms: Methylprednisolone hydrogen succinate, 6-Methylprednisolone hemisuccinate, Methylprednisolone 21-hemisuccinate, Methylprednisolone hemisuccinate, Methylprednisolone succinate, 4-[(11beta,17-Dihydroxy-6alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl)oxy]-4-oxobutanoic acid, (6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione, Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-(H succinate) (7CI), Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-(hydrogen succinate) (8CI), Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl-, 21-succinate (6CI), 6alpha-Methylprednisolone 21-succinate, 6alpha-Methylprednisolone hemisuccinate, (6α,11β)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione, 11Beta,17,21-Trihydroxy-6Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-(Hydrogen Succinate), 4-{[(6Alpha,11Beta)-11,17-Dihydroxy-6-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl]Oxy}-4-Oxobutanoic Acid, 6α-Methylprednisolone 21-succinate, 6α-Methylprednisolone hemisuccinate, Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-(H succinate), Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-(hydrogen succinate), Pregna-1,4-diene-3,20-dione, 11β,17,21-trihydroxy-6α-methyl-, 21-succinate, Pregna-1,4-diene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-, (6α,11β)-

Description

Applications 6α-Methylprednisolone 21-Hemisuccinate is a derivative of methylprednisolone (M325934), a glucocorticoid and a anti-inflammatory drug used to treat central nervous system disorders such as multiple sclerosis. 6α-Methylprednisolone 21-Hemisuccinate was examined for potential therapeutic efficacy in a model of neuroinflammation in rats with acute autoimmune encephalomyelitis.
References Gaillard, P.J., et al.: J. Controlled. Release., 164, 364 (2012);

• Brand: TRC

Chemical properties

• Molecular weight: 474.54
• Formula: C₂₆H₃₄O₈
• Color/Form: White To Off-White
• InChI: InChI=1S/C26H34O8/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31)/t14-,16-,17-,19-,23+,24-,25-,26-/m0/s1
• InChI key: InChIKey=IMBXEJJVJRTNOW-XYMSELFBSA-N
• SMILES: C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)COC(=O)CCC(=O)O)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]2(C)C=CC(=O)C=C12