Estimated delivery in United States, on Tuesday 28 May 2024
Product Information
Name:
MK-0822
Controlled Product
Synonyms:
- MK-0822,N-(1-cyanocyclopropyl)-4-fluoro-N2-{(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)biphenyl-4-yl]ethyl}-L-leucinamide
- Odanacatib
- (2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]pentanamide
- N<sup>1</sup>-[(1-Cyanocyclopropyl)-4-fluoro-N<sup>2</sup>-[(1S)-2,2,2-trifluoro-1-[4-methylsulfonyl]-1,1′-biphenyl-4-yl] ethyl]-<span class="text-smallcaps">L</span>-leucinamide
CAS:
Description:
Applications MK-0822 is a newly developed bone-targeting dual action pro-drug for osteoporosis and bone metastasis. It is also an inhibitor of cathepsin K, an enzyme involved in bone resorption.
References Arns, S., et al.: Bioorg. Medn. Chem., 20, 2131 (2012); Cusick, T., et al., J. Bone. Mineral. Rsch., 27, 524 (2013);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
525.5588
Formula:
C25H27F4N3O3S
Color/Form:
Off-White
InChI:
InChI=1S/C25H27F4N3O3S/c1-23(2,26)14-20(22(33)32-24(15-30)12-13-24)31-21(25(27,28)29)18-6-4-16(5-7-18)17-8-10-19(11-9-17)36(3,34)35/h4-11,20-21,31H,12-14H2,1-3H3,(H,32,33)/t20-,21-/m0/s1
SMILES:
CC(C)(C)n1nc(Cc2ccccc2)c(C#N)c1N
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-M425015 MK-0822
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