Mycophenolic Acid Beta-D-Glucuronide Disodium Salt

CAS: 31528-44-6

Ref. TR-M831521

Product Information

• Name: Mycophenolic Acid Beta-D-Glucuronide Disodium Salt
• Synonyms: 5-[(2E)-5-Carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl ß-D-Glucopyranosiduronic Acid Disodium Salt, Mycophenolic Acid Glucosiduronate Disodium Salt, Mycophenolic Acid Glucuronide Disodium Salt, MPAG Disodium Salt

Description

Stability Hygroscopic
Applications Mycophenolic Acid β-D-Glucuronide Disodium Salt is A metabolite of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
References Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)

• Brand: TRC

Chemical properties

• Molecular weight: 540.42
• Formula: C₂₃H₂₆Na₂O₁₂
• Color/Form: Neat
• InChI: InChI=1S/C23H28O12.2Na/c1-9(5-7-13(24)25)4-6-11-18(32-3)10(2)12-8-33-22(31)14(12)19(11)34-23-17(28)15(26)16(27)20(35-23)21(29)30;;/h4,15-17,20,23,26-28H,5-8H2,1-3H3,(H,24,25)(H,29,30);;/q;2*+1/p-2/b9-4+;;/t15-,16-,17+,20-,23+;;/m0../s1
• InChI key: InChIKey=GMOFKAUIYWUXGN-AIMYDELDSA-L
• SMILES: COc1c(C)c2c(c(O[C@@H]3O[C@H](C(=O)O[Na])[C@@H](O)[C@H](O)[C@H]3O)c1C/C=C(\C)CCC(=O)O[Na])C(=O)OC2