4-​Nitro-​2-​phenoxyphenol

CAS: 70995-08-3

Ref. TR-N496978

Product Information

• Name: 4-​Nitro-​2-​phenoxyphenol
• Synonyms: Nimesulide Imp. G (EP), Nimesulide Impurity G
• CAS: 70995-08-3

Description

Applications 4-​Nitro-​2-​phenoxyphenol is a impurity of Nimesulide (N477500), antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production. Also used in the preparation of benzoxirenes and the synthesis of trioxonins.
References Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)

• Brand: TRC

Chemical properties

• Molecular weight: 231.20
• Formula: C₁₂H₉NO₄
• Color/Form: Light Yellow
• InChI: InChI=1S/C12H9NO4/c14-11-7-6-9(13(15)16)8-12(11)17-10-4-2-1-3-5-10/h1-8,14H
• SMILES: O=[N+]([O-])c1ccc(O)c(Oc2ccccc2)c1