Product Information
Name:
NO-Aspirin 1
Synonyms:
- 2-Acetyloxybenzoic Acid 3-Nitrooxymethylphenyl Ester
- 2-(Acetyloxy)-3-[(Nitrooxy)Methyl]Phenyl Ester, Benzoic Acid
- 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester
- 2-AcetyloxybenzoicAcid3-NitrooxymethylphenylEster
- 3-((Nitrooxy)methyl)phenyl 2-acetoxybenzoate
- 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate
- 3-[(Nitrooxy)Methyl]Phenyl 2-(Acetyloxy)Benzoate
- Benzoic acid, 2-(acetyloxy)-, 3-[(nitrooxy)methyl]phenyl ester
- Ncx 4016
- Nitroaspirin
- See more synonyms
Description:
Applications NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.
References Wallace, J.F., et al.: Drug Development Res., 42, 144 (1997), Takeuchi, K, et al.: J. Physiol. Pharmacol., 49, 501 (1998), Bak, A.W., et al.: Life Sci., 62, 367 (1998), Wallace, J.L., et al.: Nature Reviews Drug Discovery, 1, 375 (2002), Chiroli, V., et al.: Eur. J. Med. Chem., 38, 441 (2003)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
331.28
Formula:
C16H13NO7
Color/Form:
White to Off-White Solid
InChI:
InChI=1S/C16H13NO7/c1-11(18)23-15-9-5-3-7-13(15)16(19)24-14-8-4-2-6-12(14)10-22-17(20)21/h2-9H,10H2,1H3
SMILES:
CC(=O)Oc1ccccc1C(=O)Oc1cccc(CO[N+](=O)[O-])c1
MDL:
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