NO-Aspirin 1

CAS: 175033-36-0

Ref. TR-N633000

Product Information

• Name: NO-Aspirin 1
• Synonyms: 2-Acetyloxybenzoic Acid 3-Nitrooxymethylphenyl Ester, 2-(Acetyloxy)-3-[(Nitrooxy)Methyl]Phenyl Ester, Benzoic Acid, 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester, 2-AcetyloxybenzoicAcid3-NitrooxymethylphenylEster, 3-((Nitrooxy)methyl)phenyl 2-acetoxybenzoate, 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate, 3-[(Nitrooxy)Methyl]Phenyl 2-(Acetyloxy)Benzoate, Benzoic acid, 2-(acetyloxy)-, 3-[(nitrooxy)methyl]phenyl ester, Ncx 4016, Nitroaspirin
• CAS: 175033-36-0

Description

Applications NO-Aspirin 1 is a hybrid molecule of aspirin and a nitric oxide (NO) donor. It contains an ester linkage, that when cleaved by esterases in the gut, liver, and plasma releases salicylate and an NO-releasing moiety. It also prevents restinosiis, inhibits proliferation of vascular smooth muscle cells, reduces infarct ssize following cardiac ischemia, and exhibits strong chemopreventative effects against colon cancer development.
References Wallace, J.F., et al.: Drug Development Res., 42, 144 (1997), Takeuchi, K, et al.: J. Physiol. Pharmacol., 49, 501 (1998), Bak, A.W., et al.: Life Sci., 62, 367 (1998), Wallace, J.L., et al.: Nature Reviews Drug Discovery, 1, 375 (2002), Chiroli, V., et al.: Eur. J. Med. Chem., 38, 441 (2003)

• Brand: TRC

Chemical properties

• Molecular weight: 331.28
• Formula: C₁₆H₁₃NO₇
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C16H13NO7/c1-11(18)23-15-9-5-3-7-13(15)16(19)24-14-8-4-2-6-12(14)10-22-17(20)21/h2-9H,10H2,1H3
• SMILES: CC(=O)Oc1ccccc1C(=O)Oc1cccc(CO[N+](=O)[O-])c1