(R,S)-Nornicotine-d4

CAS: 66148-18-3

Ref. TR-N757010

Product Information

• Name: (R,S)-Nornicotine-d4
• Synonyms: rac-Nornicotine-D4 (pyridine-D4), (±)-Nornicotine-D4, Pyridine-2,3,4,6-d4, 5-(2-pyrrolidinyl)-, Pyridine-2,3,4,6-d4, 5-(2-pyrrolidinyl)-, (±)-, 5-(2-Pyrrolidinyl)pyridine-2,3,4,6-d4, 3-(Pyrrolidin-2-yl)(< sup> 2< /sup> H< sub> 4< /sub> )pyridine, Pyridine-2,3,4,6-D< Sub> 4< /Sub> , 5-(2-Pyrrolidinyl)-
• CAS: 66148-18-3

Description

Stability Light Sensitive
Applications Labelled (RS)-Nornicotine (N757000). (RS)-Nornicotine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity.
References Hecht, S., et al.: Carcinogenesis, 9, 875 (1988), Rivenson, A., et al.: Cancer Res., 48, 6912 (1988), Hoffmann, D., et al.: Chem. Res. Toxicol., 14, 767 (2001), Kool, J., et al.: J. Med. Chem., 49, 3287 (2006), Kool, J., et al.: Drug Metab. Dispos., 35, 640 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 152.23
• Formula: C₉H₈D₄N₂
• Color/Form: Colourless
• InChI: InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2/i1D,3D,5D,7D
• InChI key: InChIKey=MYKUKUCHPMASKF-DNZPNURCSA-N
• SMILES: [2H]c1nc([2H])c(C2CCCN2)c([2H])c1[2H]