Palbociclib N-β-D-Glucuronide Sodium Salt (Technical Grade, ~65%)

CAS: 571190-30-2

Ref. TR-P139910

Product Information

• Name: Palbociclib N-β-D-Glucuronide Sodium Salt (Technical Grade, ~65%)
• Synonyms: 6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(1-piperazinyl)-2-pyridinyl)amino)pyrido[2,3-d]pyridin-7(8H)-one, 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one, 6-Acetyl-8-cyclopentyl-5-methyl-2-[[5-(piperazin-1-yl)pyridin-2-yl]amino]-8H-pyrido[2,3-d]pyrimidin-7-one, 6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one, Ibrance, Otava-Bb 1115529, Palbociclib, Palbociclib base, Palbocyclib, Pd 332991, Pd 991, Pd-0332991, Pd0332991, Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-

Description

Applications Palbociclib N-β-D-Glucuronide is a derivative of Palbociclib (P139900) which is an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
References Finn, R., et al.: Breast Cancer Res., 11, 5 (2009)

• Brand: TRC

Chemical properties

• Molecular weight: 645.64
• Formula: C₃₀H₃₆N₇NaO₈
• Purity: ~65%
• Color/Form: Neat
• InChI: InChI=1S/C30H37N7O8.Na/c1-15-19-14-32-30(34-26(19)37(17-5-3-4-6-17)27(42)21(15)16(2)38)33-20-8-7-18(13-31-20)35-9-11-36(12-10-35)28-24(41)22(39)23(40)25(45-28)29(43)44;/h7-8,13-14,17,22-25,28,39-41H,3-6,9-12H2,1-2H3,(H,43,44)(H,31,32,33,34);/q;+1/p-1/t22-,23-,24+,25-,28+;/m0./s1
• InChI key: InChIKey=JKYWRZIQJOFHII-CMKFJBAYSA-M
• SMILES: CC(=O)c1c(C)c2cnc(Nc3ccc(N4CCN([C@@H]5O[C@H](C(=O)O[Na])[C@@H](O)[C@H](O)[C@H]5O)CC4)cn3)nc2n(C2CCCC2)c1=O