Palonosetron-3-ene N-Oxide

CAS: 1021456-82-5

Ref. TR-P165820

Product Information

• Name: Palonosetron-3-ene N-Oxide
• Synonyms: 1H-Benz[de]isoquinolin-1-one, 2,4,5,6-tetrahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]-, 2,4,5,6-Tetrahydro-2-[(3S)-1-oxido-1-azabicyclo[2.2.2]oct-3-yl]-1H-benz[de]isoquinolin-1-one
• CAS: 1021456-82-5

Description

Applications Palonosetron-3-ene N-Oxide is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)

• Brand: TRC

Chemical properties

• Molecular weight: 310.39
• Formula: C₁₉H₂₂N₂O₂
• Color/Form: Off-White to Pale Yellow Solid
• InChI: InChI=1S/C19H22N2O2/c22-19-16-6-2-4-14-3-1-5-15(18(14)16)11-20(19)17-12-21(23)9-7-13(17)8-10-21/h2,4,6,11,13,17H,1,3,5,7-10,12H2/t13?,17-,21?/m1/s1
• InChI key: InChIKey=UJTMVWDDYCEVNT-IBBFCSCYSA-N
• SMILES: O=c1c2cccc3c2c(cn1[C@H]1C[N+]2([O-])CCC1CC2)CCC3