Estimated delivery in United States, on Friday 28 Jun 2024
Product Information
Name:
Pamapimod
Synonyms:
- 6-(2,4-difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
- 6-(2,4-Difluorophenoxy)-2-[[3-hydroxy-1-(2-hydroxyethyl)propyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one
- R 1503
- Ro 4402257
CAS:
Description:
Applications A selective inhibitor of the α-isoform of p38 MAP kinase. It is used in in treatment of patient with rheumatoid arthritis. Pamapimod was tolerable but not effective as Methotrexate.
References Guan, Z., et al.: J. Biol. Chem., 273, 12901 (1998), Lee, J., et al.: Pharmacol. Ther., 82, 389 (1999), Korb, A., et al.: Arthritis Rheum., 54, 2745 (2006),
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
406.38
Formula:
C19H20F2N4O4
Color/Form:
White
InChI:
InChI=1S/C19H20F2N4O4/c1-25-17-11(10-22-19(24-17)23-13(4-6-26)5-7-27)8-16(18(25)28)29-15-3-2-12(20)9-14(15)21/h2-3,8-10,13,26-27H,4-7H2,1H3,(H,22,23,24)
InChI key:
InChIKey=JYYLVUFNAHSSFE-UHFFFAOYSA-N
SMILES:
Cn1c(=O)c(Oc2ccc(F)cc2F)cc2c[nH]c(=NC(CCO)CCO)nc21
MDL:
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HS code:
Technical inquiry about: TR-P167500 Pamapimod
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