PF-3644022

CAS: 1276121-88-0

Ref. TR-P293825

Product Information

• Name: PF-3644022
• Synonyms: (10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one
• CAS: 1276121-88-0

Description

Applications PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.
References Hegen, M., et al.: J. Immunol., 177, 1913 (2006), Anderson, D., et al.: J. Med. Chem., 50, 2647 (2007), Goldberg, D., et al.: Bioorg. Med. Chem. Lett., 18, 938 (2008), Burnette, B., et al.: Pharmacology, 84, 42 (2009), Mourey, et al.: J. Pharmacol. Exp. Ther., 333, 797 (2010),

• Brand: TRC

Chemical properties

• Molecular weight: 374.46
• Formula: C₂₁H₁₈N₄OS
• Color/Form: Off-White to Yellow Solid
• InChI: InChI=1S/C21H18N4OS/c1-11-3-4-13(10-22-11)15-6-5-14-16(25-15)7-8-17-18(14)19-20(27-17)21(26)24-12(2)9-23-19/h3-8,10,12,23H,9H2,1-2H3,(H,24,26)/t12-/m1/s1
• InChI key: InChIKey=CMWRPDHVGMHLSZ-GFCCVEGCSA-N
• SMILES: Cc1ccc(-c2ccc3c(ccc4sc5c(c43)NC[C@@H](C)NC5=O)n2)cn1