Imidazolo-oxindole PKR inhibitor C16(PKR Inhibitor)

CAS: 608512-97-6

Ref. TR-P572500

Product Information

• Name: Imidazolo-oxindole PKR inhibitor C16(PKR Inhibitor)
• Synonyms: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one, 6,8-Dihydro-8-(1H-imidazol-4-ylmethylene)- 7H-pyrrolo[2,3-g]benzothiazol-7-one, GW 506033X

Description

Applications PKR Inhibitor is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.
References Jammi, N., et al.: Biochem. Biophys. Res. Commun., 308, 50 (2003); Ingrand, S., et al.: Neurosci. Lett., 409, 192 (2006); Chen, H., et al.: Eur. J. Neurosci., 28, 2003 (2008); Couturier, J., et al.: J. Biol. Chem., 285, 1272 (2010)

• Brand: TRC

Chemical properties

• Molecular weight: 268.29
• Formula: C₁₃H₈N₄OS
• Color/Form: Neat
• InChI: InChI=1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
• InChI key: InChIKey=VFBGXTUGODTSPK-BAQGIRSFSA-N
• SMILES: O=C1Nc2ccc3ncsc3c2/C1=C/c1c[nH]cn1