Baricitinib Acetic Acid Impurity
CAS: 2271228-52-3
Ref. TR-P852230
| 1mg | Discontinued | ||
| 5mg | Discontinued | ||
| 10mg | Discontinued |
Product Information
Name:
Baricitinib Acetic Acid Impurity
Synonyms:
- 3-Azetidineacetic acid
- 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]- (ACI)
- 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetic acid (ACI)
- 2-[1-ethylsulfonyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]azetidin-3-yl]acetic acid
Description:
Applications 2-(3-(4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetic Acid is an impurity of Baricitinib (B118690), which is a JAK1 and JAK2 inhibitor and has been studied as a promising treatment for rheumatoid arthritis.
References Dasari, S., et. al.: Russ. J. Org., 55, 1569 (2019);Zhang, F., et. al.: Faming Zhuanli Shenqing 11pp. Patent (2018), CN 108976233 A 20181211;Greenwald, L., et. al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J., et. al.: J. Immunol., 184, 5298 (2010);
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
390.417
Formula:
C16H18N6O4S
Color/Form:
White to Off-White Solid
InChI:
InChI=1S/C16H18N6O4S/c1-2-27(25,26)21-8-16(9-21,5-13(23)24)22-7-11(6-20-22)14-12-3-4-17-15(12)19-10-18-14/h3-4,6-7,10H,2,5,8-9H2,1H3,(H,23,24)(H,17,18,19)
InChI key:
InChIKey=IBIZRHDJANJRHP-UHFFFAOYSA-N
SMILES:
CCS(=O)(=O)N1CC(CC(=O)O)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1
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