2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinoline

CAS: 1796933-62-4

Ref. TR-Q550630

Product Information

• Name: 2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinoline
• CAS: 1796933-62-4

Description

Applications 2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinoline is an intermediate in the sythesis of (S,S)-Palonosetron Acid which is an impurity in the synthesis of (S,S) Palonosetron (P165800), serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.
References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993), Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995), Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003), Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004), Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 282.42
• Formula: C₁₉H₂₆N₂
• Color/Form: Yellow Solid
• InChI: InChI=1S/C19H22O2/c1-5-6-14-10-17(20)19(18(21)11-14)16-9-13(4)7-8-15(16)12(2)3/h7-11,20-21H,2,5-6H2,1,3-4H3
• InChI key: InChIKey=COURSARJQZMTEZ-UHFFFAOYSA-N
• SMILES: C=C(C)c1ccc(C)cc1-c1c(O)cc(CCC)cc1O