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Product Information
Name:
R 788 Sodium Salt Hydrate
Controlled Product
Synonyms:
- 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one Sodium Salt Hydrate
- Fostamatinib Disodium Hydrate
- R 935788 sodium Hydrate
- R 788 sodium Hydrate
CAS:
Description:
Applications R 788 Sodium Salt Hydrate is a sodium hydrate form of R 788 which is a selective spleen tyrosine kinase (Syk) inhibitor. It may be used in the treatment of autoimmune diseases such as type 1 diabetes and has been tested in the treatment of rheumatoid athritis, leukemia and lymphoma.
References Colonnna, L., et al.: J. Immunol., 185, 1532 (2010); McAdoo, S., et al.: Drug Future, 36, 273 (2011); Efremov, D., et al.: Expert Opin. Inv. Drug., 20, 623 (2011);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
624.421801
Formula:
C23H24FN6Na2O9P•x(H2O)
Color/Form:
Neat
InChI:
InChI=1S/C23H26FN6O9P.2Na.H2O/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;;1H2/q;2*+1;/p-2
InChI key:
InChIKey=YCDSTEMYIROFPG-UHFFFAOYSA-L
SMILES:
COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O[Na])O[Na])C(=O)C(C)(C)O4)n2)cc(OC)c1OC.O
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-R070115 R 788 Sodium Salt Hydrate
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