Sacubitril-d4

CAS: 1884269-07-1

Ref. TR-S080897

Product Information

• Name: Sacubitril-d4
• Synonyms: [1,1'-Biphenyl]-4-pentanoic acid, ?-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-a-methyl-, a-ethyl ester, (aR,?S)-, (2R,4S)-4-[(3-Carboxy-1-oxopropyl-2,2,3,3-d4)amino]-4-[(p-phenylphenyl)methyl]-2-methylbutanoic acid ethyl ester, (2R,4S)-5-(Biphenyl-4-yl)-4-[(3-carboxypropionyl-2,2,3,3-d4)amino]-2-methylpentanoic acid ethyl ester, AHU 377-d4, Sacubitril-D4 (succinate-D4), Sucabitril-d4
• CAS: 1884269-07-1

Description

Applications Isotope labelled Sacubitril is an antihypertensive drug used in combination with Valsartan (V095750). The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

• Brand: TRC

Chemical properties

• Molecular weight: 415.52
• Formula: C₂₄H₂₅D₄NO₅
• Color/Form: Light Yellow
• InChI: InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1/i13D2,14D2
• InChI key: InChIKey=PYNXFZCZUAOOQC-JKBMVCCKSA-N
• SMILES: [2H]C([2H])(C(=O)O)C([2H])([2H])C(=O)NC(Cc1ccc(-c2ccccc2)cc1)C[C@@H](C)C(=O)OCC