SB 242084

CAS: 181632-25-7

Ref. TR-S154450

Product Information

• Name: SB 242084
• Synonyms: 6-chloro-5-methyl-N-[6-(2-methylpyridin-3-yl)oxypyridin-3-yl]-2,3-dihydroindole-1-carboxamide;dihydrochloride, 1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxamide, 6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride, 6-Chloro-5-methyl-1-[(2-[2-methylpyrid-3-yloxy]pyrid-5yl)carbamoyl]indoline dihydrochloride, SB242084 diHCl, SB242084 hydrate dihydrochloride, Sb 242084
• CAS: 181632-25-7

Description

Applications SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. SB 242084 displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors.SB 242084 os a brain penetrant; exerts anxiolytic-like activity.
References Bromidge, et al.: J. Med. Chem., 40, 3494 (1997), Kennet, et al.: Neuropharmacology, 36, 609 (1997), Dalton, et al.: Psychopharmacology, 185, 45 (2006),

• Brand: TRC

Chemical properties

• Molecular weight: 467.78
• Formula: C₂₁H₁₉ClN₄O₂
• Color/Form: Neat
• InChI: InChI=1S/C21H19ClN4O2.2ClH/c1-13-10-15-7-9-26(18(15)11-17(13)22)21(27)25-16-5-6-20(24-12-16)28-19-4-3-8-23-14(19)2;;/h3-6,8,10-12H,7,9H2,1-2H3,(H,25,27);2*1H
• InChI key: InChIKey=GIUZEIJUFOPTMR-UHFFFAOYSA-N
• SMILES: Cc1cc2c(cc1Cl)N(C(=O)Nc1ccc(Oc3cccnc3C)nc1)CC2