Estimated delivery in United States, on Tuesday 25 Jun 2024
Product Information
Name:
SCH772984
Controlled Product
Synonyms:
- (3R)-1-[2-Oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide
- (R)-1-(2-Oxo-2-(4-(4-(pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-6-yl)pyrrolidine-3-carboxamide
CAS:
Description:
Applications SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models.
References Morris, E. J., et. al.: Cancer Discovery, 3, 742 (2013)
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
587.67
Formula:
C33H33N9O2
Color/Form:
Pale Yellow Solid
InChI:
InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1
InChI key:
InChIKey=BLQVZMZFPOBLQG-RUZDIDTESA-N
SMILES:
O=C(Nc1ccc2c(-c3ccncc3)n[nH]c2c1)[C@@H]1CCN(CC(=O)N2CCN(c3ccc(-c4ncccn4)cc3)CC2)C1
MDL:
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EINECS:
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HS code:
Technical inquiry about: TR-S199940 SCH772984
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