(1S,3S)-Solifenacin Hydrochloride

CAS: 180468-38-6

Ref. TR-S676715

Product Information

• Name: (1S,3S)-Solifenacin Hydrochloride
• Synonyms: 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, (3S)-1-azabicyclo[2.2.2]oct-3-yl ester, hydrochloride (1:1), (1S)-, 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, (3S)-1-azabicyclo[2.2.2]oct-3-yl ester, monohydrochloride, (1S)- (9CI), 2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-1-phenyl-, 1-azabicyclo[2.2.2]oct-3-yl ester, monohydrochloride, [S-(R*,R*)]-, (1S,3'S)-Solifenacin hydrochloride, Solifenacin S,S-diastereomer, (S)-Quinuclidin-3-yl (S)-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxylate hydrochloride, (1S)-3,4-Dihydro-1-phenyl-2(1H)-isoquinolinecarboxylic Acid (3S)-1-Azabicyclo-[2.2.2]oct-3-yl Ester Hydrochloride
• CAS: 180468-38-6

Description

Applications (1S,3S-)Solifenacin Hydrochloride is an optical isomer of Solifenacin Hydrochloride (S676700), a muscarinic M3 receptor antagoinst. Used in treatment of urinary incontinence.
References Ikeda K., et al.: Arch. Pharmacol., 366, 97, (2002), Chapple, C.R., et al.: Br. J. Urol., 93, 303 (2004), Ohtake, A., et al.: Eur. J. Pharmacol., 492, 243 (2004), Brunton, S., et al.: Curr. Med. Res. Opin., 21, 71 (2005), Habb, F., et al.: Eur. Urol. 47, 376 (2005), Payne, C.K., et al.: Drugs, 66, 175 (2006); Naito, R. et al.: J. Med. Chem., 48, 6597 (2005);

• Brand: TRC

Chemical properties

• Molecular weight: 398.9257
• Formula: C₂₃H₂₇ClN₂O₂
• Color/Form: Yellowish Solid
• InChI: InChI=1S/C23H26N2O2.ClH/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19;/h1-9,18,21-22H,10-16H2;1H/t21-,22+;/m1./s1
• InChI key: InChIKey=YAUBKMSXTZQZEB-NSLUPJTDSA-N
• SMILES: Cl.O=C(O[C@@H]1C[N@]2CC[C@@H]1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1