Sumanirole Maleate

CAS: 179386-44-8

Ref. TR-S790700

Product Information

• Name: Sumanirole Maleate
• Synonyms: (5R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-Butenedioate, (R)-5,6-Dihydro-5-(methylamino)-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (2Z)-2-Butenedioate, Sumanirole maleate, U-95666(free base), U-95666E, Pnu-95666E, Pnu-95666A, U-95666A
• CAS: 179386-44-8

Description

Applications Sumanirole is a high affinity D2 receptor agonist (EC50 values are between 17 and 75 nM in cell-based assays). Sumanirole displays >200-fold selectivity for the D2 receptor against other dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively). Sumanirole exhibits antiParkinsonian activity similar to Ropinirole (R641000).
References McCall, et al.: J. Pharmacol. Exp. Ther., 314 1248 (2005), Stephenson, et al.: J. Pharmacol. Exp. Ther., 314 1257 (2005),

• Brand: TRC

Chemical properties

• Molecular weight: 319.313
• Formula: C₁₅H₁₇N₃O₅
• Color/Form: Off-White to Light Beige Solid
• InChI: InChI=1S/C11H13N3O.C4H4O4/c1-12-8-5-7-3-2-4-9-10(7)14(6-8)11(15)13-9;5-3(6)1-2-4(7)8/h2-4,8,12H,5-6H2,1H3,(H,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-/t8-;/m1./s1
• InChI key: InChIKey=RKZSNTNMEFVBDT-MRVPVSSYSA-N
• SMILES: CN[C@@H]1Cc2cccc3[nH]c(=O)n(c23)C1