Tamoxifen-13C6

CAS: 1346606-38-9

Ref. TR-T006002

Product Information

• Name: Tamoxifen-13C6
• Synonyms: (Z)-2-[4-[1-(phenyl-13C6)-2-phenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine, ICI 47699-13C6, Mammaton-13C6, Novaldex-13C6, Z-Tamoxifen-13C6, trans-Tamoxifen-13C6

Description

Applications A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.
References Sutherland, R., et al.: Nature, 267, 434 (1977); Lerner, L., et al.: Cancer Res., 50, 4177 (1990); Love, R., et al.: J. Clin. Oncol., 20 2559 (2002);

• Brand: TRC

Chemical properties

• Molecular weight: 377.47
• Formula: C₂₀₁₃C₆H₂₉NO
• Color/Form: Neat
• InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-/i6+1,9+1,10+1,13+1,14+1,22+1
• InChI key: InChIKey=NKANXQFJJICGDU-JTAPQUQISA-N
• SMILES: CC/C(=C(/c1ccc(OCCN(C)C)cc1)[13c]1[13cH][13cH][13cH][13cH][13cH]1)c1ccccc1