Terlipressin-Phe(d5) Diacetate Salt

CAS: 14636-12-5

Ref. TR-T115802

Product Information

• Name: Terlipressin-Phe(d5) Diacetate Salt
• Synonyms: 1-Triglycyl-8-lysine Vasopressin-d5 Diacetate Salt, Glycylpressin Diacetate Salt, Glypressin-d5 Diacetate Salt, Na-Gly-Gly-Gly-8-Lys-vasopressin-d5 Diacetate Salt, Na-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin-d5 Diacetate Salt, Na-Glycyl-glycyl-glycyl-lysine-vasopressin-d5 Diacetate Salt, Na-Glycylglycylglycyl-vasopressin-d5 Diacetate Salt, Remestyp-d5 Diacetate Salt, Triglycyl-8-lysine-vasopressin-d5 Diacetate Salt, [N-a-Triglycyl-8-lysine]-vasopressin-d5 Diacetate Salt, N-(N-(N-Glycylglycyl)Glycyl)-8-L-Lysinevasopressin, (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-[[2-[(2-Aminoacetyl)Amino]Acetyl]Amino]Acetyl]Amino]-13-Benzyl-10-(2-Carbamoylethyl)-7-(Carbamoylmethyl)-16-[(4-Hydroxyphenyl)Methyl]-6,9,12,15,18-Pentaoxo-1,2-Dithia-5,8,11,14,17-Pentazacycloicosane-4-Carbonyl]-N-[(1S)-5-Amino-1-(Carbamoylmethylcarbamoyl)Pentyl]Pyrrolidine-2-Carboxamide, (2S)-1-{[(4R,7S,10S,13S,16S,19R)-19-{[({[(aminoacetyl)amino]acetyl}amino)acetyl]amino}-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl]carbonyl}-N-{(2S)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl}pyrrolidine-2-carboxamide (non-preferred name), Terlipressin Acetate, [N-α-Triglycyl-8-lysine]-vasopressin, 1-Triglycyl-8-lysine vasopressin, Glycylpressin, Glypressin, Nα-Glycyl-glycyl-glycyl-[8-lysine]-vasopressin, Nα-Glycyl-glycyl-glycyl-lysine-vasopressin, Nα-Glycylglycylglycyl-vasopressin, Nα-Gly-Gly-Gly-8-Lys-vasopressin, Remestyp, Terlipressina, Terlipressine, Triglycyl-8-lysine-vasopressin, Vasopressin, N-(glycylglycylglycyl)-8-L-lysine-, Vasopressin, N-[N-(N-glycylglycyl)glycyl]-8-L-lysine-

Description

Applications Isotope labelled Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. Terlipressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. Terlipressin is also used in the treatment of acute variceal bleeding.
References Uriz, J. et al.: J. Heptol., 33, 43 (2000); O'Brien, A. et al.: Lancet, 359, 1209 (2002); Burroughs, A.K. et al.: Digestion, 59, 26 (1998); Villanueva, C. et al.: Am. J. Gastroenterol., 100, 624 (2005);

• Brand: TRC

Chemical properties

• Molecular weight: 1352.5
• Formula: C₅₆H₇₇D₅N₁₆O₁₉S₂
• Color/Form: Off White Solid
• InChI: InChI=1S/C52H74N16O15S2.C2H4O2/c53-17-5-4-9-31(45(76)60-23-41(57)72)63-51(82)38-10-6-18-68(38)52(83)37-27-85-84-26-36(61-44(75)25-59-43(74)24-58-42(73)22-54)50(81)65-34(20-29-11-13-30(69)14-12-29)48(79)64-33(19-28-7-2-1-3-8-28)47(78)62-32(15-16-39(55)70)46(77)66-35(21-40(56)71)49(80)67-37;1-2(3)4/h1-3,7-8,11-14,31-38,69H,4-6,9-10,15-27,53-54H2,(H2,55,70)(H2,56,71)(H2,57,72)(H,58,73)(H,59,74)(H,60,76)(H,61,75)(H,62,78)(H,63,82)(H,64,79)(H,65,81)(H,66,77)(H,67,80);1H3,(H,3,4)/t31-,32-,33+,34-,35-,36-,37-,38-;/m0./s1/i1D,2D,3D,7D,8D
• InChI key: InChIKey=BYDVFOPTAIPAGA-BHIKFBBFSA-N
• SMILES: CC(=O)O.[2H]c1c([2H])c([2H])c(C[C@H]2NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)CSSC[C@@H](C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC2=O)c([2H])c1[2H]