Tetradecylthioacetic Acid

CAS: 2921-20-2

Ref. TR-T292625

Product Information

• Name: Tetradecylthioacetic Acid
• Synonyms: TTA, 1-Mono(carboxymethylthio)tetradecane, (Tetradecylsulfanyl)Acetic Acid, 2-(Tetradecylthio)acetic acid, Acetic acid, (tetradecylthio)-, Acetic acid, 2-(tetradecylthio)-, Tetradcylthioacetic Acid
• CAS: 2921-20-2

Description

Applications TTA is a novel thio-fatty acid which cannot undergo beta-oxidation. It induces apoptosis in IPC-81 leukemia cells via depolarization of mitochondrial membrane potential and inhibits glioma cell proliferation. TTA completely prevents high fat diet-induced insulin resistance and adiposity in Wistar rats. Activates rodent PPAR’s with rank order PPARα>PPARδ>PPARγ.
References Madsen, L., et al.: J. Lipid Res., 43, 742 (2002), Kronstad, K.J., et al.: Chem. Biol., 10, 609 (2003, Berge, K., et al.: J. Lipid Res., 44, 118 (2003),

• Brand: TRC

Chemical properties

• Molecular weight: 288.49
• Formula: C₁₆H₃₂O₂S
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C16H32O2S/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-19-15-16(17)18/h2-15H2,1H3,(H,17,18)
• InChI key: InChIKey=IPBCWPPBAWQYOO-UHFFFAOYSA-N
• SMILES: CCCCCCCCCCCCCCSCC(=O)O