1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one

CAS: 137977-97-0

Ref. TR-T296000

Product Information

• Name: 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one
• Synonyms: 1-(4-Amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
• CAS: 137977-97-0

Description

Applications 1,2,3,4-Tetrahydro-1-(4-amino-2-methylbenzoyl)-7-chloro-5H-1-benzazepin-5-one is an intermediate used in the synthetic preparation of Tolvaptan (T536650), a selective nonpeptide arginine vasopressin V2 receptor antagonist.
References Kondo, K., et al.: Bioorg. Med. Chem., 7, 1743 (1999); Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006)

• Brand: TRC

Chemical properties

• Molecular weight: 328.79
• Formula: C₁₈H₁₇ClN₂O₂
• Color/Form: Off-White to Pale Yellow Solid
• InChI: InChI=1S/C18H17ClN2O2/c1-11-9-13(20)5-6-14(11)18(23)21-8-2-3-17(22)15-10-12(19)4-7-16(15)21/h4-7,9-10H,2-3,8,20H2,1H3
• InChI key: InChIKey=FLJCJPKXJWRZJB-UHFFFAOYSA-N
• SMILES: Cc1cc(N)ccc1C(=O)N1CCCC(=O)c2cc(Cl)ccc21